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Ivermectin 12 mg typically stays in your system for about 12 to 16 hours, but its effects can last longer depending on the type of infection being treated. The medication reaches peak levels in the blood within 4–5 hours after taking it. Although most of the drug is eliminated through the liver and intestines within a day or two, traces can remain for up to a week. Factors like age, liver health, and other medications may affect how long it stays in your body. Always follow your doctor’s instructions for safe and effective use.